In-depth: Monodisperse microbubbles

“The next generation of ultrasound contrast agents” Tide Micro fluidics

Our innovative platform technology used for the production of monodisperse microbubbles and microparticles is based on microfluidic techniques. We have a patented technique which allows us to create microparticles of uniform and accurately controlled size at very high production rates. Microfluidic devices are known for their ability to create microdroplets, bubbles or particles with high monodispersity. This is due to the techniques of particles generation, where each bubble or droplet is created individually. A downside to standard microfluidic techniques is the low production rates that are achievable, something our technology is able to overcome.

Our Microfluidic technology

We use flow focussing techniques for the production of microparticles. This technique uses the outer fluid, or continuous phase, and the geometry of the microfluidic chip to confine the inner fluid, or disperse phase. As the fluids flow through the junction the disperse phase is confined and focussed creating a point where it will break-up into small droplets or bubbles of uniform size. A schematic of this geometry can be seen below.

The applications that this geometry allows are diverse, with gas/liquid mixtures microbubbles can be created and liquid/liquid mixtures allow microdropletes to be created. It is even possible to create solid microparticles either through chemical reactions or post production treatments such as UV exposure. Using this geometry for large volume production means that uniform dispersions and emulsions can be made and slight modifications to the design can allow double emulsions or Janus droplets, those with a two component core, to be created.